Computational Ophthalmology – Page 4 – big data. machine learning. data science.

January 5, 2021March 12, 2021

Multicenter, Head-to-Head, Real-World Validation Study of Seven Automated Artificial Intelligence Diabetic Retinopathy Screening Systems

In this article published in the journal Diabetes Care, Dr. Aaron Lee and his co-authors put diabetic retinopathy screening algorithms to the test in the real world, evaluating them on retinal images from nearly 24,000 veterans who sought diabetic retinopathy screening at two Veterans Affairs health care systems (Seattle and Atlanta). These screening algorithms are designed to check patients who might be at risk for retinopathy, a potential complication of diabetes that can lead to blindness if left untreated. Based on performance in clinical trials, one of these algorithms is approved for use in the US, and several others are in clinical use in other countries. Dr. Lee wanted to know how well they worked outside of the clinical trial setting, however, when faced with real world data from a diverse group of patients in a variety of clinical settings.

December 20, 2020March 12, 2021

Exploring a Structural Basis for Delayed Rod-Mediated Dark Adaptation in Age-Related Macular Degeneration Via Deep Learning

Pubmed

Journal

Citation

In this study, Dr. Aaron Lee, Dr. Cecilia Lee and their co-authors used a unique artificial intelligence approach for identifying novel anatomic biomarkers in the retinas of patients with age-related macular degeneration. Patients with this condition can progressively lose their central vision, and there are still no effective treatments for the more common dry (non exudative) form of the disease. Delayed rod-mediated dark adaptation is the method through which the retina recovers after a stimulus of bright light, and this process can be measured as a function of time to help predict which patients are at risk for age-related macular degeneration and vision loss. The authors wanted to take advantage of the increasingly advanced retinal imaging technology available to search for structural changes in the retina that might be associated with dark adaptation dysfunction, to better understand the cellular and structural pathology that occurs early the in age-related macular degeneration disease process.

November 1, 2020January 12, 2021

Minimum data set for SD‐OCT retinal imaging and analysis from the Atlas of Retinal Imaging in Alzheimer's Study

Pubmed

Journal

Citation

In this article, a group of authors representing 16 different institutions (including our own Dr. Cecilia Lee) have laid out a framework for standardization of retinal imaging data collection for Alzheimer's disease biomarker research studies. Many labs are doing research in this area, but they often use different imaging modalities and protocols, making it challenging to compare data between studies. Because these studies often have small numbers of subjects by necessity, standardizing data collection will also enable researchers to collect data into a larger database, allowing them to observe larger trends in the data.

October 1, 2020October 16, 2020

Retinal Biomarkers of Alzheimer's Disease

Journal

Citation

In this perspective article for the American Journal of Ophthalmology, Dr. Lee and Dr. Apte summarize the current understanding of retinal changes associated with Alzheimer's disease that have been identified thanks to recent advances in imaging technology. Some of these imaging findings correlate with known pathologic findings, and some are associated with cognitive decline. The authors discuss the current understanding of how these retinal changes may be related to neurodegeneration or other AD-related brain pathology on a cellular level.

The eye offers a unique window into the brain, as the neurons in the eye are a direct extension of the central nervous system and share the same embryonic development. Researchers have known for decades that optic nerve degeneration, the loss of retinal ganglion cells, and thinning of the retinal nerve fiber layer are associated with Alzheimer's disease based on pathological examination of post-mortem eyes, but recent developments in imaging technologies such as optical coherence tomography (OCT) allow physicians to easily assess these changes during a regular eye exam. New imaging techniques have also led to the discovery of new retinal biomarkers.

September 15, 2020October 15, 2020

Big data requirements for artificial intelligence

Pubmed

Journal

Citation

In this article for the journal Current Opinion in Ophthalmology, Dr. Wang and her co-authors discuss the evolution of big data and artificial intelligence technologies in medicine, and describe some of the problems that must be addressed for big data to successfully enable the next generation of artificial intelligence.

Big data research has benefitted from important technological advances in recent years. Artificial intelligence research depends on large amounts of data, often collected from multiple institutions, in order to be most effective. More powerful computing resources, implementation of electronic health records, improved data collection, and efforts to create standards for data exchange have all helped researchers aggregate larger datasets. But there are still some important limitations to accessing big data for this kind of research, which the authors discuss in detail.