Research Papers

• Lacy M, Kung TPH, Owen JP, Yanigihara RT, Blazes M, Pershing S, Hyman LG, Van Gelder RN, Lee AY, Lee CS, IRIS® Registry Analytic Center Consortium. Endophthalmitis Rate in Immediately Sequential versus Delayed Sequential Bilateral Cataract Surgery within the Intelligent Research in Sight (IRIS) Registry Data. July 2021. doi.org/10.1016/j.ophtha.2021.07.008. Read more about this paper here...

• Owen JP, Blazes M, Manivannan N, Lee GC, Yu S, Durbin MK, Nair A, Singh RP, Talcott KE, Melo AG, Greenlee T, Chen ER, Conti TF, Lee CS, Lee AY. Student becomes teacher: training faster deep learning lightweight networks for automated identification of optical coherence tomography B-scans of interest using a student-teacher framework. Biomedical Optics Express. 2021. Vol. 12, Issue 9, pp. 5387-5399. doi.org/10.1364/BOE.433432. Read more about this paper here...

• Bagdasarova Y, Lee AY, Maring M, Wen J, Lacy M, Lee CS, Chen A. Cataract Surgery Is Not Associated with Decreased Risk of Retinal Vein Occlusion. Ophthalmology Science. 2021. Vol 1, Issue 3. doi.org/10.1016/j.xops.2021.100041

• Owen JP, Blazes M, Lacy M, Yanigihara RT, Van Gelder RN, Lee AY, Lee CS, IRIS Research Analytic Center Consortium. Refractive Outcomes After Immediate Sequential vs Delayed Sequential Bilateral Cataract Surgery. JAMA Ophthalmology. July 2021;139(8):876-885. doi:10.1001/jamaophthalmol.2021.2032. Read more about this paper here...

• McKay KM, Apostolopoulos N, Dahrouj M, Nguyen HV, Reddy A, Blazes M, Lacy M, Pepple KL, Lee AY, Lee CS. Assessing the Uniformity of Uveitis Clinical Concepts and Associated ICD-10 Codes Across Health Care Systems Sharing the Same Electronic Health Records System. JAMA Ophthalmology.  2021;139(8):887-894. doi:10.1001/jamaophthalmol.2021.2045

• Lin AC, Lee CS, Blazes M, Lee AY, Gorin MB. Assessing the Clinical Utility of Expanded Macular OCTs Using Machine Learning. Translational Vision Science & Technology. May 2021, Vol.10, 32. doi.org/10.1167/tvst.10.6.32

• Legocki AT, Moshiri Y, Zepeda EM, Gillette TB, Shariff A, Grant LE, Ding L, Lee AY, Lee CS, Tarczy-Hornoch K, Cabrera MT. Dome-shaped macula in premature infants visualized by handheld spectral-domain optical coherence tomography. J AAPOS. 2021 June. Vol 25, Issue 3. doi.org/10.1016/j.jaapos.2020.12.007

• Gale R, Pikoula M, Lee AY, Denaxas S, Egan C, Tufail A, Taylor P. Real world evidence on 5661 patients treated for macular oedema secondary to branch retinal vein occlusion with intravitreal anti-vascular endothelial growth factor, intravitreal dexamethasone or macular laser. Br J Ophthalmol. 2021 Apr;105(4):549-554. doi: 10.1136/bjophthalmol-2020-315836. Epub 2020 Jun 12. PubMed PMID: 32532760; PubMed Central PMCID: PMC8005793.

• Lee CS, Latimer CS, Henriksen JC, Blazes M, Larson EB, Crane PK, Keene CD, Lee AY. Application of deep learning to understand resilience to Alzheimer's disease pathology. Brain Pathology. 2021 May 19; doi.org/10.1111/bpa.12974. Read more about this paper here...

• Brummen AV, Owen JP, Spaide T, Froines C, Lu R, Lacy M, Blazes M, Li E, Lee CS, Lee AY, Zhang M. PeriorbitAI: Artificial intelligence automation of eyelid and periorbital measurements. Am J Ophthalmology. Epub 2021 May 16. doi: 10.1016/j.ajo.2021.05.007. PMID: 34010596.

• Lee CS, Lee ML, Gibbons LE, Yanagihara RT, Blazes M, Kam JP, McCurry SM, Bowen JD, McCormick, WC, Lee AY, Larson EB, Crane PK. Associations between retinal artery/vein occlusions and risk of vascular dementia. J Alzheimers Dis. 2021 Mar 15. doi: 10.3233/JAD-201492. Online ahead of print. Read more about this paper here...

• Cole E, Valikodath NG, Maa A, Chan RVP, Chiang MF, Lee AY, Tu DC, Hwang TS. Bringing Ophthalmic Graduate Medical Education into the 2020s with Information Technology. Ophthalmology. 2021 Mar;128(3):349-353. doi: 10.1016/j.ophtha.2020.11.019. Epub 2020 Dec 24. PubMed PMID: 33358411; PubMed Central PMCID: PMC8168378.

• Nakamichi K, Shen JZ, Lee CS, Lee A, Roberts EA, Simonson PD, Roychoudhury P, Andriesen J, Randhawa AK, Mathias PC, Greninger AL, Jerome KR, Van Gelder RN. Hospitalization and mortality associated with SARS-CoV-2 viral clades in COVID-19. Scientific Reports. 11 Article number: 4802 (2021 Feb 26). doi.org/10.1038/s41598-021-82850-9. PMID: 33637820

• Maloca PM, Müller PL, Lee AY, Tufail A, Balaskas K, Niklaus S, Kaiser P, Suter S, Zarranz-Ventura J, Egan C, Scholl HPN, Schnitzer TK, Singer T, Hasler PW, Denk M. Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligence. Communications Biology. 2021 Feb 5. 4(1):170. doi: 10.1038/s42003-021-01697-y. PMID: 33547415

• Boland MV, Cocoran KJ, Lee AY. Changes in performance of glaucoma surgeries 1994-2017 based on claims and payment data for US Medicare beneficiaries. Ophthalmology Glaucoma. 2021 Jan 30. doi: 10.1016/j.ogla.2021.01.004 [Epub ahead of print] 

• Thomas DS, Lee AY, Müller PL, Schwartz R, Olvera-Barrios A, Warwick AN, Patel PJ, Heeren TFC, Egan C, Taylor P, Tufail A. Contextualising Single-Arm Trials With Real-World Data: An Emulated Target Trial Comparing Therapies For Neovascular Age-Related Macular Degeneration. Clin Transl Sci. 2021 Jan 9;. doi: 10.1111/cts.12974. [Epub ahead of print] PubMed PMID: 33421321

• Lee AY, Yanagihara RT, Lee CS, Blazes M, Jung HC, Chee YE, Gencarella MD, Gee H, Maa AY, Cockerham GC, Lynch M, Boyko EJ. Multicenter, Head-to-Head, Real-World Validation Study of Seven Automated Artificial Intelligence Diabetic Retinopathy Screening Systems. Diabetes Care. 2021 Jan 5;. doi: 10.2337/dc20-1877. [Epub ahead of print] PubMed PMID: 33402366. Read more about this paper here...

2020

• Lee AY, Lee CS, Blazes MS, Owen JP, Bagdasarova Y, Wu Y, Spaide T, Yanagihara RT, Kihara Y, Clark ME, Kwon M, Owsley C, Curcio CA. Exploring a Structural Basis for Delayed Rod-Mediated Dark Adaptation in Age-Related Macular Degeneration Via Deep Learning. Transl Vis Sci Technol. 2020 Dec;9(2):62. doi: 10.1167/tvst.9.2.62. eCollection 2020 Dec. PubMed PMID: 33344065; PubMed Central PMCID: PMC7745629. Read more about this paper here...

• Campbell JP, Lee AY, Abràmoff M, Keane PA, Ting DSW, Lum F, Chiang MF. Reporting Guidelines for Artificial Intelligence in Medical Research. Ophthalmology. 2020 Dec;127(12):1596-1599. doi: 10.1016/j.ophtha.2020.09.009. Epub 2020 Sep 10. PubMed PMID: 32920029.

• Alber J, Arthur E, Sinoff S, DeBuc DC, Chew E, Douquette L, Hatch W, Hudson C, Kashani A, Lee CS, Montaquila S, Modzbar S, Cuhha LP, Tayyari F, Van Stavern G, Synder PJ. Minimum data set for SD‐OCT retinal imaging and analysis from the Atlas of Retinal Imaging in Alzheimer's Study. Alzheimers Dement. Volume 12, November 2020, Page e12119. doi.org/10.1002/dad2.12119 Read more about this paper here...

• Lee CS, Apte RS. Retinal Biomarkers of Alzheimer’s Disease. Am J Ophthalmol. Volume 218, October 2020, Pages 337- 341. doi.org/10.1016/j.ajo.2020.04.040 Read more about this paper here...

• Hunt MS, Kihara Y, Lee AY. Novel Low-Shot Deep Learning Approach for Retinal Image Classification With Few Examples. JAMA Ophthalmol. 2020 Oct 1;138(10):1077-1078. doi: 10.1001/jamaophthalmol.2020.3256. PubMed PMID: 32880607.

• Mehta N, Lee CS, Mendonça LSM, Raza K, Braun PX, Duker, JS, Waheed NK, Lee AY. Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation. JAMA Ophthalmol. 2020; Aug 6;e202769. doi:10.1001/jamaophthalmol.2020.2769. PMID: 32761143.

• Gale R, Gill C, Pikoula M, Lee AY, Hanson RLW, Denaxas S, Egan C, Tufail A, Taylor P. Multicentre study of 4626 patients assesses the effectiveness, safety and burden of two categories of treatments for central retinal vein occlusion: intravitreal anti-vascular endothelial growth factor injections and intravitreal Ozurdex injections. Br J Ophthalmol. 2020 Sep 22;. doi: 10.1136/bjophthalmol-2020-317306. [Epub ahead of print] PubMed PMID: 32962992.

• Miller DD, Stewart MW, Gagne JJ, Wagner AL, Lee AY. Differences in characteristics of Medicare patients treated by ophthalmologists and optometrists. PLoS One. 2020;15(9):e0227783. doi: 10.1371/journal.pone.0227783. eCollection 2020. PubMed PMID: 32925977; PubMed Central PMCID: PMC7489526.

• Liu X, Cruz Rivera S, Moher D, Calvert MJ, Denniston AK; SPIRIT-AI and CONSORT-AI Working Group. Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension. Nature Medicine. 2020; 26: 1364–1374. doi: https://doi.org/10.1038/s41591-020-1034-x. PMID: 32908283.

• Cruz Rivera S, Liu X, Chan AW, Denniston AK, Calvert MJ; SPIRIT-AI and CONSORT-AI Working Group; SPIRIT-AI and CONSORT-AI Steering Group; SPIRIT-AI and CONSORT-AI Consensus Group. Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension. Nature Medicine. 2020; 26: 1351–1363. doi: https://doi.org/10.1038/s41591-020-1037-7. PMID: 32908284.

• Rim TH, Lee AY, Ting DS, Teo K, Betzler BK, Teo ZL, Yoo TK, Lee G, Kim Y, Lin AC, Kim SE, Tham YC, Kim SS, Cheng CY, Wong TY, Cheung CMG. Detection of features associated with neovascular age-related macular degeneration in ethnically distinct data sets by an optical coherence tomography: trained deep learning algorithm. Br J Ophthalmol. 2020. Sep 9;bjophthalmol-2020-316984. doi: 10.1136/bjophthalmol-2020-316984 Online ahead of print. PMID: 32907811.

• Wang SY, Pershing S, Lee AY. Big data requirements for artificial intelligence. Curr Opin Ophthalmol. 2020 Sep;31(5):318-323. doi: 10.1097/ICU.0000000000000676. Review. PubMed PMID: 32657996. Read more about this paper here...

• Rivera SC, Liu X, Chan AW, Denniston AK, Calvert MJ. Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI Extension. BMJ. 2020 Sep 9;370:m3210. doi: 10.1136/bmj.m3210. PubMed PMID: 32907797; PubMed Central PMCID: PMC7490785.

• Parrish RK 2nd, Pasquale LR, Lee AY, Folberg R, Stewart MW, Duncan Powers SL. Who Could Know Who I Am? The Possibility of Patient Identification With Retinal Imaging. Am J Ophthalmol. 2020 Aug;216:A3-A4. doi: 10.1016/j.ajo.2020.03.039. Epub 2020 May 18. PubMed PMID: 32456787.

• Li A, Palejwala NV, Shantha J, O'Keefe G, Lee CS, Albini T, Yeh S. Long-term multimodal imaging in acute posterior multifocal placoid pigment epitheliopathy and association with coxsackievirus exposure. PLoS One. 2020;  Aug 24;15(8):e0238080. doi: 10.1371/journal.pone.0238080. PMID: 32834009

• Tom E, Keane PA, Blazes M, Pasquale LR, Chiang MF, Lee AY, Lee CS. Protecting Data Privacy in the Age of AI-Enabled Ophthalmology. Transl Vis Sci Technol. 2020 Jul;9(2):36. doi: 10.1167/tvst.9.2.36. eCollection 2020 Jul. PubMed PMID: 32855840; PubMed Central PMCID: PMC7424948. Read more about this paper here...

• Lee CS, Owen JP, Yanagihara RT, Lorch A, Pershing S, Hyman L, Miller JW, Haller JA, Chiang MF, Lum F, Lee AY. Smoking Is Associated with Higher Intraocular Pressure Regardless of Glaucoma. Ophthalmology Glaucoma, 2020. Accepted. NIHMSID: NIHMS1580730. Read more about this paper here...

• Kuo DE, Wei MM, Knickelbein JE, Armbrust KR, Yeung IYL, Lee AY, Chan CC, Sen HN. Logistic Regression Classification of Primary Vitreoretinal Lymphoma versus Uveitis by Interleukin 6 and Interleukin 10 Levels. Ophthalmology. 2020 Feb 5. Feb 5. pii: S0161-6420(20)30085-3. doi: 10.1016/j.ophtha.2020.01.042. [Epub ahead of print]. Read more about this paper here...

• Gale R, Pikoula M,Lee AY, Denaxas S, Egan C, Tufail A, Taylor P; UK EMR Users Group. Real world evidence on 5661 patients treated for macular oedema secondary to branch retinal vein occlusion with intravitreal anti-vascular endothelial growth factor, intravitreal dexamethasone or macular laser. Br J Ophthalmol. 2020 Jun 12:bjophthalmol-2020-315836. doi: 10.1136/bjophthalmol-2020-315836. Online ahead of print. PMID: 32532760.

• Lee CS, Lee ML, Yanagihara RT, Lee AY. Predictors of narrow angle detection rate-a longitudinal study of Massachusetts residents over 1.7 million person years. Eye (Lond). 2020 Jun 3. doi: 10.1038/s41433-020-1003-0. Online ahead of print.PMID: 32494044. Read more about this paper here...

• Lee CS, Lee AY. Clinical applications of continual learning machine learning. Lancet Digit Health. 2020 Jun;2(6):e279-e281. doi: 10.1016/S2589-7500(20)30102-3. PubMed PMID: 33328120.

• Petersen CA, Mehta P, Lee AY. Data-Driven, Feature-Agnostic Deep Learning vs Retinal Nerve Fiber Layer Thickness for the Diagnosis of Glaucoma. JAMA Ophthalmol. 2020 Apr 1;138(4):339-340. doi: 10.1001/jamaophthalmol.2019.6143. PubMed PMID: 32053135. Read more about this paper here...

• Agrawal R, Testi I, Lee CS et al. Evolving consensus for immunomodulatory therapy (IMT) in non-infectious uveitis (NIU) during the COVID-19 pandemic. British J Ophth. 2020. doi: 10.1136/bjophthalmol-2020-316776. [published online ahead of print, 2020 Jun 25]. PMID: 32586933. Read more about this paper here...

• Thng ZX, De Smet MD, Lee CS, Gupta V, Smith JR, McCluskey PJ, Thorne JE, Kempen JH, Zierhut M, Nguyen QE, Pavesio C, Agrawal R. COVID-19 and immunosuppression: a review of current clinical experiences and implications for ophthalmology patients taking immunosuppressive drugs. Br J Ophthomol. 2020 Jun : bjophthalmol-2020-316586. doi: 10.1136/bjophthalmol-2020-316586

• Spaide T, Wu Y, Yanagihara RT, Fang S, Ghabra O, Yi JS, Chen PP, Moses F, Lee AY, Wen JC. Using Deep Learning to Automate Goldmann Applanation Tonometry Readings. Ophthalmology. 2020 April 25. pii: S0161-6420(20)30412-7. doi: 10.1016/j.ophtha.2020.04.033. [Epub ahead of print] PMID: 32344074. Read more about this paper here...

• Hojjaite S, Lee CS. Defining Geographic Atrophy in the Asian Population Using the Asian Eye Epidemiology Consortium. Ophthalmology. 2020; 127(10):1382-1383. doi: 10.1016/j.ophtha.2020.05.009. PMID: 32951674.

• Legocki AT, Zepeda EM, Gillette TB, Grant LE, Shariff A, Touch P, Lee AY, Ding L, Estrada MM, Tarczy-Hornoch K,Lee CS, Mayock DE, Pepple KL, Cabrera MT. Vitreous Findings by Handheld Spectral-Domain OCT Correlate with Retinopathy of Prematurity Severity. Ophthalmol Retina. 2020 Apr 9:S2468-6530(20)30129-9. doi: 10.1016/j.oret.2020.03.027. Online ahead of print. PMID: 32446843.

• Lee CS, Hong B, Kasi S, Aderman C, Talcott K, Adam M, Yue B, Akileswaran L, Nakamichi K, Wu Y, Rezaei KA, Olmos de Koo LC, Chee YE, Lee AY, Garg SJ, Van Gelder RN, Endophthalmitis Study Group. Prognostic utility of whole genome sequencing and polymerase chain reaction tests of ocular fluids in post-procedural endophthalmitis. American journal of ophthalmology. Am J Opthalmol. 2020 Mar 23. pii: S0002-9394(20)30106-9. doi: 10.1016/j.ajo.2020.03.008. [Epub ahead of print] PMID: 32217118. Read more about this paper here...

• Fraser MS, Wachira BW, Flaxman AD, Lee AY, Duber HC. Impact of traffic, poverty and facility ownership on travel time to emergency care in Nairobi, Kenya. Afr J Emerg Med. 2020 Mar;10(1):40-45. doi: 10.1016/j.afjem.2019.12.003. Epub 2020 Jan 14. PubMed PMID: 32161711; PubMed Central PMCID: PMC7058857.

• Yanagihara RT, Lee CS, Ting DSW, Lee AY. Methodological Challenges of Deep Learning in Optical Coherence Tomography for Retinal Diseases: A Review. Transl Vis Sci Technol. 2020 Feb 18;9(2):11. doi: 10.1167/tvst.9.2.11. Review. PubMed PMID: 32704417; PubMed Central PMCID: PMC7347025. Read more about this paper here...

• Lee CS, Lee AY. How Artificial Intelligence Can Transform Randomized Controlled Trials. Transl Vis Sci Technol. 2020 Feb 12;9(2):9. doi: 10.1167/tvst.9.2.9. PubMed PMID: 32704415; PubMed Central PMCID: PMC7346875. Read more about this paper here...

• Lee CS, Yanagihara RT, Lee AY. Using Deep Learning Models to Characterize Major Retinal Features on Color Fundus Photographs. Ophthalmology. 2020 Jan;127(1):95-96. doi: 10.1016/j.ophtha.2019.07.014. PubMed PMID: 31864476.

2019

• Wu Y, Luttrell I, Feng S, Chen PP, Spaide T, Lee AY, Wen JC. Development and validation of a machine learning, smartphone-based tonometer. Br J Ophthalmol. 2019 Dec 23;. doi: 10.1136/bjophthalmol-2019-315446. [Epub ahead of print] PubMed PMID: 31871048. Read more about this paper here...

• Ting DSW, Lee AY, Wong TY. An Ophthalmologist's Guide to Deciphering Studies in Artificial Intelligence. Ophthalmology. 2019 Nov;126(11):1475-1479. doi: 10.1016/j.ophtha.2019.09.014. Epub 2019 Sep 21. PubMed PMID: 31635697; PubMed Central PMCID: PMC7339681.

• Fasler K, Fu DJ, Moraes G, Wagner S, Gokhale E, Kortuem K, Chopra R, Faes L, Preston G, Pontikos N, Patel PJ, Tufail A, Lee AY, Balaskas K, Keane PA. Moorfields AMD database report 2: fellow eye involvement with neovascular age-related macular degeneration. Br J Ophthalmol. 2019 Oct 14;. doi: 10.1136/bjophthalmol-2019-314446. [Epub ahead of print] PubMed PMID: 31611234.

• Bojikian KD, Lee CS, Lee AY. Finding Glaucoma in Color Fundus Photographs Using Deep Learning. JAMA Ophthalmol. 2019 Sep 12;. doi: 10.1001/jamaophthalmol.2019.3512. [Epub ahead of print] PubMed PMID: 31513255; PubMed Central PMCID: PMC7335661.

• Maloca PM, Lee AY, de Carvalho ER, Okada M, Fasler K, Leung I, Hormann B, Kaiser P, Suter S, Hasler PW, Zarranz-Ventura J, Egan C, Heeren TFC, Balaskas K, Tufail A, Scholl HPN. Validation of automated artificial intelligence segmentation of optical coherence tomography images. PLoS One. 2019;14(8):e0220063. doi: 10.1371/ journal.pone.0220063. eCollection 2019. PubMed PMID: 31419240; PubMed Central PMCID: PMC6697318. Read more about this paper here...

• Boland MV, Hwang TS, Lim MC, Peterson JL, Lum F, Lee AY. Medicare Incentive Payments to United States Ophthalmologists for Use of Electronic Health Records: 2011-2016. Ophthalmology. 2019 Jul;126(7):928-934. doi: 10.1016/j.ophtha.2019 .01.030. Epub 2019 Feb 13. PubMed PMID: 30768941; PubMed Central PMCID: PMC6662572. Read more about this paper here...

• Fasler K, Moraes G, Wagner S, Kortuem KU, Chopra R, Faes L, Preston G, Pontikos N, Fu DJ, Patel P, Tufail A, Lee AY, Balaskas K, Keane PA. One- and two-year visual outcomes from the Moorfields age-related macular degeneration database: a retrospective cohort study and an open science resource.BMJ Open. 2019 Jun 21;9(6):e027441. doi: 10.1136/bmjopen-2018-027441. PubMed PMID: 31230012; PubMed Central PMCID: PMC6596999.

• Vangipuram G, Lee AY, Rezaei KA, Olmos De Koo LC, Chee YE, Chao JR, Egan C, Lee CS. CAPTCHA as a Visual Performance Metric in Active Macular Disease. J Ophthalmol. 2019;2019:6710754. doi: 10.1155/2019/6710754. eCollection 2019. PubMed PMID: 31281669; PubMed Central PMCID: PMC6590550.

• Denniston AK, Lee AY, Lee CS, Crabb DP, Bailey C, Lip PL, Taylor P, Pikoula M, Cook E, Akerele T, Antcliff R, Brand C, Chakravarthy U, Chavan R, Dhingra N, Downey L, Eleftheriadis H, Ghanchi F, Khan R, Kumar V, Lobo A, Lotery A, Menon G, Mukherjee R, Palmer H, Patra S, Paul B, Sim DA, Talks JS, Wilkinson E, Tufail A, Egan CA. United Kingdom Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group: report 4, real-world data on the impact of deprivation on the presentation of diabetic eye disease at hospital services. Br J Ophthalmol. 2019 Jun;103(6):837-843. doi: 10.1136/bjophthalmol-2018-312568. Epub 2018 Sep 29. PubMed PMID: 30269098; PubMed Central PMCID: PMC6582816.

• Pepple KL, Nguyen MH, Pakzad-Vaezi K, Williamson K, Odell N, Lee C, Leveque TK, Van Gelder RN. RESPONSE OF INFLAMMATORY CYSTOID MACULAR EDEMA TO TREATMENT USING ORAL ACETAZOLAMIDE. Retina. 2019 May;39(5):948-955. doi: 10.1097/IAE.0000000000002044. PubMed PMID: 29346240; PubMed Central PMCID: PMC6047935.

• Wen JC, Lee CS, Keane PA, Xiao S, Rokem AS, Chen PP, Wu Y, Lee AY. Forecasting future Humphrey Visual Fields using deep learning. PLoS One. 2019;14(4):e0214875. doi: 10.1371/journal.pone.0214875. eCollection 2019. PubMed PMID: 30951547; PubMed Central PMCID: PMC6450620. Read more about this paper here...

• Lee, AY. Machine Diagnosis. Nature. 2019 Apr 10. doi: 10.1038/d41586-019-01112-x. Online ahead of print. Read more about this paper here...

• Lee CS, Tyring AJ, Wu Y, Xiao S, Rokem AS, DeRuyter NP, Zhang Q, Tufail A, Wang RK, Lee AY. Generating retinal flow maps from structural optical coherence tomography with artificial intelligence. Sci Rep. 2019 Apr 5;9(1):5694. doi: 10.1038/s41598-019- 42042-y. PubMed PMID: 30952891; PubMed Central PMCID: PMC6450899. Read more about this paper here...

• Ting DSW, Pasquale LR, Peng L, Campbell JP, Lee AY, Raman R, Tan GSW, Schmetterer L, Keane PA, Wong TY. Artificial intelligence and deep learning in ophthalmology. Br J Ophthalmol. 2019 Feb;103(2):167-175. doi: 10.1136/bjophthalmol-2018-313173. Epub 2018 Oct 25. Review. PubMed PMID: 30361278; PubMed Central PMCID: PMC6362807.

• Lee CS, Larson EB, Gibbons LE, Latimer CS, Rose SE, Hellstern LL, Keene CD, Crane PK. Ophthalmology-Based Neuropathology Risk Factors: Diabetic Retinopathy is Associated with Deep Microinfarcts in a Community-Based Autopsy Study. J Alzheimers Dis. 2019;68(2):647-655. doi: 10.3233/JAD-181087. PubMed PMID: 30883356; PubMed Central PMCID: PMC6450649. Read more about this paper here...

• Kihara Y, Heeren TFC, Lee CS, Wu Y, Xiao S, Tzaridis S, Holz FG, Charbel Issa P, Egan CA, Lee AY. Estimating Retinal Sensitivity Using Optical Coherence Tomography With Deep-Learning Algorithms in Macular Telangiectasia Type 2. JAMA Netw Open. 2019 Feb 1;2(2):e188029. doi: 10.1001/jamanetworkopen.2018.8029. PubMed PMID: 30735236; PubMed Central PMCID: PMC6484597. Read more about this paper here...

• Lee CS, Larson EB, Gibbons LE, Lee AY, McCurry SM, Bowen JD, McCormick WC, Crane PK. Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease. Alzheimers Dement. 2019 Jan;15(1):34-41. doi: 10.1016/j.jalz.2018.06.2856. Epub 2018 Aug 8. PubMed PMID: 30098888; PubMed Central PMCID: PMC6333518. Read more about this paper here...

2018

• Lee A, Taylor P, Kalpathy-Cramer J, Tufail A. Reply. Ophthalmology. 2018 Dec;125(12):e86. doi: 10.1016/j.ophtha.2018.06.036. Epub 2018 Oct 19. PubMed PMID: 30343936.

• Lee AY, Lee CS, Pieters M, Maa AY, Cockerham G, Lynch MG. Differences in Tertiary Glaucoma Care in the Veterans Affairs Health Care System. JAMA Ophthalmol. 2018 Nov 1;136(11):1227-1234. doi: 10.1001/jamaophthalmol.2018.3463. PubMed PMID: 30128546; PubMed Central PMCID: PMC6224299.

• Lee CS, Lee AY, Akileswaran L, Stroman D, Najafi-Tagol K, Kleiboeker S, Chodosh J, Magaret A, Wald A, Van Gelder RN. Determinants of Outcomes of Adenoviral Keratoconjunctivitis. Ophthalmology. 2018 Sep;125(9):1344-1353. doi: 10.1016/ j.ophtha.2018.02.016. Epub 2018 Mar 27. PubMed PMID: 29602567; PubMed Central PMCID: PMC6109430. Read more about this paper here...

• Mehta H, Tufail A, Daien V, Lee AY, Nguyen V, Ozturk M, Barthelmes D, Gillies MC. Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors. Prog Retin Eye Res. 2018 Jul;65:127-146. doi: 10.1016/j.preteyeres.2017.12.002. Epub 2018 Jan 2. Review. PubMed PMID: 29305324.

• Balaratnasingam C, An D, Sakurada Y, Lee CS, Lee AY, McAllister IL, Freund KB, Sarunic M, Yu DY. Comparisons Between Histology and Optical Coherence Tomography Angiography of the Periarterial Capillary-Free Zone. Am J Ophthalmol. 2018 May;189:55-64. doi: 10.1016/j.ajo.2018.02.007. Epub 2018 Feb 19. PubMed PMID: 29470970; PubMed Central PMCID: PMC6132062.

• Lee CS, Kim AJ, Baughman D, Egan C, Bailey C, Johnston RL, Natha S, Khan R, Brand C, Akerele T, McKibbin M, Downey L, Al-Husainy S, Lee AY, Tufail A. VISUAL ACUITY IMPROVEMENT WHEN SWITCHING FROM RANIBIZUMAB TO AFLIBERCEPT IS NOT SUSTAINED. Retina. 2018 May;38(5):951-956. doi: 10.1097/IAE.0000000000001637. PubMed PMID: 28406859; PubMed Central PMCID: PMC5636644. Read more about this paper here...

• Lee AY, Butt T, Chew E, Agron E, Clemons TE, Egan CA, Lee CS, Tufail A. Cost-effectiveness of age-related macular degeneration study supplements in the UK: combined trial and real-world outcomes data. Br J Ophthalmol. 2018 Apr;102(4):465-472. doi: 10.1136/bjophthalmol-2017-310939. Epub 2017 Aug 23. PubMed PMID: 28835423; PubMed Central PMCID: PMC5825252. Read more about this paper here...

• Ho CW, Agarwal A, Lee CS, Chhablani J, Gupta V, Khatri M, Nirmal J, Pavesio C, Agrawal R. A Review of the Role of Intravitreal Corticosteroids as an Adjuvant to Antibiotics in Infectious Endophthalmitis. Ocul Immunol Inflamm. 2018;26(3):461-468. doi: 10.1080/09273948.2016.1245758. Epub 2016 Nov 16. Review. PubMed PMID: 27849402; PubMed Central PMCID: PMC5557691.

2017

• Xiao S, Bucher F, Wu Y, Rokem A, Lee CS, Marra KV, Fallon R, Diaz-Aguilar S, Aguilar E, Friedlander M, Lee AY. Fully automated, deep learning segmentation of oxygen-induced retinopathy images. JCI Insight. 2017 Dec 21;2(24). doi: 10.1172/jci.insight.97585. PubMed PMID: 29263301; PubMed Central PMCID: PMC5752269. Read more about this paper here...

• Lee AY, Lee CS, Egan CA, Bailey C, Johnston RL, Natha S, Hamilton R, Khan R, Al-Husainy S, Brand C, Akerele T, Mckibbin M, Downey L, Tufail A. UK AMD/DR EMR REPORT IX: comparative effectiveness of predominantly as needed (PRN) ranibizumab versus continuous aflibercept in UK clinical practice. Br J Ophthalmol. 2017 Dec;101(12):1683-1688. doi: 10.1136/bjophthalmol-2016-309818. Epub 2017 May 6. PubMed PMID: 28478396; PubMed Central PMCID: PMC5673590. Read more about this paper here...

• Denniston AK, Chakravarthy U, Zhu H, Lee AY, Crabb DP, Tufail A, Bailey C, Akerele T, Al-Husainy S, Brand C, Downey L, Fitt A, Khan R, Kumar V, Lobo A, Mahmood S, Mandal K, Mckibbin M, Menon G, Natha S, Ong JM, Tsaloumas MD, Varma A, Wilkinson E, Johnston RL, Egan CA. The UK Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group, Report 2: real-world data for the impact of cataract surgery on diabetic macular oedema. Br J Ophthalmol. 2017 Dec;101(12):1673-1678. doi: 10.1136/bjophthalmol-2016-309838. Epub 2017 May 9. PubMed PMID: 28487377.

• Lee CS, Su GL, Baughman DM, Wu Y, Lee AY. Disparities in delivery of ophthalmic care; An exploration of public Medicare data. PLoS One. 2017;12(8):e0182598. doi: 10.1371/journal.pone.0182598. eCollection 2017. PubMed PMID: 28787015; PubMed Central PMCID: PMC5546578. Read more about this paper here...

• Lee CS, Lee AY, Baughman D, Sim D, Akelere T, Brand C, Crabb DP, Denniston AK, Downey L, Fitt A, Khan R, Mahmood S, Mandal K, Mckibbin M, Menon G, Lobo A, Kumar BV, Natha S, Varma A, Wilkinson E, Mitry D, Bailey C, Chakravarthy U, Tufail A, Egan C. The United Kingdom Diabetic Retinopathy Electronic Medical Record Users Group: Report 3: Baseline Retinopathy and Clinical Features Predict Progression of Diabetic Retinopathy. Am J Ophthalmol. 2017 Aug;180:64-71. doi: 10.1016/j.ajo.2017.05.020. Epub 2017 May 29. PubMed PMID: 28572062; PubMed Central PMCID: PMC5608549. Read more about this paper here...

• Lin AD, Lee AY, Zhang Q, Rezaei KA, Kinyoun J, Wang RK, Lee CS. Association between OCT-based microangiography perfusion indices and diabetic retinopathy severity. Br J Ophthalmol. 2017 Jul;101(7):960-964. doi: 10.1136/bjophthalmol-2016-309514. Epub 2016 Nov 15. PubMed PMID: 27852582; PubMed Central PMCID: PMC5536958.

• Lee CS, Tyring AJ, Deruyter NP, Wu Y, Rokem A, Lee AY. Deep-learning based, automated segmentation of macular edema in optical coherence tomography. Biomed Opt Express. 2017 Jul 1;8(7):3440-3448. doi: 10.1364/BOE.8.003440. eCollection 2017 Jul 1. PubMed PMID: 28717579; PubMed Central PMCID: PMC5508840. Read more about this paper here...

• Lee JH, Agarwal A, Mahendradas P, Lee CS, Gupta V, Pavesio CE, Agrawal R. Viral posterior uveitis. Surv Ophthalmol. 2017 Jul - Aug;62(4):404-445. doi: 10.1016/j.survophthal.2016.12.008. Epub 2016 Dec 22. Review. PubMed PMID: 28012878; PubMed Central PMCID: PMC5654632.

• Lee CS, Baughman DM, Lee AY. Deep learning is effective for the classification of OCT images of normal versus Age-related Macular Degeneration. Ophthalmol Retina. 2017 Jul-Aug;1(4):322-327. doi: 10.1016/j.oret.2016.12.009. Epub 2017 Feb 13. PubMed PMID: 30693348; PubMed Central PMCID: PMC6347658. Read more about this paper here...

• Su GL, Baughman DM, Zhang Q, Rezaei K, Lee AY, Lee CS. Comparison of retina specialist preferences regarding spectral-domain and swept-source optical coherence tomography angiography. Clin Ophthalmol. 2017;11:889-895. doi: 10.2147/OPTH.S135479. eCollection 2017. PubMed PMID: 28553068; PubMed Central PMCID: PMC5440072.

• Tufail A, Rudisill C, Egan C, Kapetanakis VV, Salas-Vega S, Owen CG, Lee AY, Louw V, Anderson J, Liew G, Bolter L, Srinivas S, Nittala M, Sadda S, Taylor P, Rudnicka AR. Automated Diabetic Retinopathy Image Assessment Software: Diagnostic Accuracy and Cost-Effectiveness Compared with Human Graders. Ophthalmology. 2017 Mar;124(3):343-351. doi: 10.1016/j.ophtha.2016.11.014. Epub 2016 Dec 23. PubMed PMID: 28024825.

• Baughman DM, Lee CS, Snydsman BE, Jung HC. Bilateral Uveitis and Keratitis Following Nivolumab Treatment for Metastatic Melanoma. Med Case Rep (Wilmington). 2017;3(2). doi: 10.21767/2471-8041.100044. Epub 2017 Apr 14. PubMed PMID: 28856338; PubMed Central PMCID: PMC5573243.

• Baughman DM, Su GL, Tsui I, Lee CS, Lee AY. Validation of the Total Visual Acuity Extraction Algorithm (TOVA) for Automated Extraction of Visual Acuity Data From Free Text, Unstructured Clinical Records. Transl Vis Sci Technol. 2017 Mar;6(2):2. doi: 10.1167/tvst.6.2.2. eCollection 2017 Mar. PubMed PMID: 28299240; PubMed Central PMCID: PMC5347661. Read more about this paper here...

• Zhang Q, Zhang A, Lee CS, Lee AY, Rezaei KA, Roisman L, Miller A, Zheng F, Gregori G, Durbin MK, An L, Stetson PF, Rosenfeld PJ, Wang RK. Projection artifact removal improves visualization and quantitation of macular neovascularization imaged by optical coherence tomography angiography. Ophthalmol Retina. 2017 Mar-Apr;1(2):124-136. doi: 10.1016/j.oret.2016.08.005. PubMed PMID: 28584883; PubMed Central PMCID: PMC5455345.

• Egan C, Zhu H, Lee AY, Sim D, Mitry D, Bailey C, Johnston R, Chakravarthy U, Denniston A, Tufail A, Khan R, Mahmood S, Menon G, Akerele T, Downey L, McKibbin M, Varma A, Lobo A, Wilkinson E, Fitt A, Brand C, Tsaloumas M, Mandal K, Kumar V, Natha S, Crabb D. The United Kingdom Diabetic Retinopathy Electronic Medical Record Users Group, Report 1: baseline characteristics and visual acuity outcomes in eyes treated with intravitreal injections of ranibizumab for diabetic macular oedema. Br J Ophthalmol. 2017 Jan;101(1):75-80. doi: 10.1136/bjophthalmol-2016-309313. Epub 2016 Dec 13. PubMed PMID: 27965262.

2016

• Tufail A, Kapetanakis VV, Salas-Vega S, Egan C, Rudisill C, Owen CG, Lee AY, Louw V, Anderson J, Liew G, Bolter L, Bailey C, Sadda S, Taylor P, Rudnicka AR. An observational study to assess if automated diabetic retinopathy image assessment software can replace one or more steps of manual imaging grading and to determine their cost-effectiveness. Health Technol Assess. 2016 Dec;20(92):1-72. doi: 10.3310/hta20920. PubMed PMID: 27981917; PubMed Central PMCID: PMC5204130.

• Lee CS, Morris A, Van Gelder RN, Lee AY. Evaluating Access to Eye Care in the Contiguous United States by Calculated Driving Time in the United States Medicare Population. Ophthalmology. 2016 Dec;123(12):2456-2461. doi: 10.1016/j.ophtha.2016.08.015. Epub 2016 Sep 12. PubMed PMID: 27633646; PubMed Central PMCID: PMC5608548. Read more about this paper here...

• Madhusudhana KC, Lee AY, Keane PA, Chakravarthy U, Johnston RL, Egan CA, Sim D, Zarranz-Ventura J, Tufail A, McKibbin M. UK Neovascular Age-Related Macular Degeneration Database. Report 6: time to retreatment after a pause in therapy. Outcomes from 92 976 intravitreal ranibizumab injections. Br J Ophthalmol. 2016 Dec;100(12):1617-1622. doi: 10.1136/bjophthalmol-2015-308077. Epub 2016 Mar 30. PubMed PMID: 27030276.

• Lee AY, Zhang Q, Baughman DM, Mudumbai R, Wang RK, Lee CS. Evaluation of bilateral central retinal artery occlusions with optical coherence tomography-based microangiography: a case report. J Med Case Rep. 2016 Nov 1;10(1):307. doi: 10.1186/s13256-016-1095-0. PubMed PMID: 27802835; PubMed Central PMCID: PMC5090894.

• Johnston RL, Lee AY, Buckle M, Antcliff R, Bailey C, McKibbin M, Chakravarthy U, Tufail A. UK Age-Related Macular Degeneration Electronic Medical Record System (AMD EMR) Users Group Report IV: Incidence of Blindness and Sight Impairment in Ranibizumab-Treated Patients. Ophthalmology. 2016 Nov;123(11):2386-2392. doi: 10.1016/j.ophtha.2016.07.037. Epub 2016 Sep 9. PubMed PMID: 27615601.

• Liew G, Lee AY, Zarranz-Ventura J, Stratton I, Bunce C, Chakravarthy U, Lee CS, Keane PA, Sim DA, Akerele T, McKibbin M, Downey L, Natha S, Bailey C, Khan R, Antcliff R, Armstrong S, Varma A, Kumar V, Tsaloumas M, Mandal K, Egan C, Johnston RL, Tufail A. The UK Neovascular AMD Database Report 3: inter-centre variation in visual acuity outcomes and establishing real-world measures of care. Eye (Lond). 2016 Nov;30(11):1462-1468. doi: 10.1038/eye.2016.149. Epub 2016 Jul 15. PubMed PMID: 27419839; PubMed Central PMCID: PMC5108012.

• Tan HY, Agarwal A, Lee CS, Chhablani J, Gupta V, Khatri M, Nirmal J, Pavesio C, Agrawal R. Management of noninfectious posterior uveitis with intravitreal drug therapy. Clin Ophthalmol. 2016;10:1983-2020. doi: 10.2147/OPTH.S89341. eCollection 2016. Review. PubMed PMID: 27789936; PubMed Central PMCID: PMC5068474.

• Lee CS, Randhawa S, Lee AY, Lam DL, Van Gelder RN. Patterns of Laboratory Testing Utilization Among Uveitis Specialists. Am J Ophthalmol. 2016 Oct;170:161-167. doi: 10.1016/j.ajo.2016.08.004. Epub 2016 Aug 10. PubMed PMID: 27521608; PubMed Central PMCID: PMC5056154. Read more about this paper here...

• Doan T, Akileswaran L, Andersen D, Johnson B, Ko N, Shrestha A, Shestopalov V, Lee CS, Lee AY, Van Gelder RN. Paucibacterial Microbiome and Resident DNA Virome of the Healthy Conjunctiva. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5116-5126. doi: 10.1167/iovs.16-19803. PubMed PMID: 27699405; PubMed Central PMCID: PMC5054734.

• Kee AR, Gonzalez-Lopez JJ, Al-Hity A, Gupta B, Lee CS, Gunasekeran DV, Jayabalan N, Grant R, Kon OM, Gupta V, Westcott M, Pavesio C, Agrawal R. Anti-tubercular therapy for intraocular tuberculosis: A systematic review and meta-analysis. Surv Ophthalmol. 2016 Sep-Oct;61(5):628-53. doi: 10.1016/j.survophthal.2016.03.001. Epub 2016 Mar 10. Review. PubMed PMID: 26970263; PubMed Central PMCID: PMC5061337.

• Lee AY, Lee CS, Van Gelder RN. Scalable metagenomics alignment research tool (SMART): a scalable, rapid, and complete search heuristic for the classification of metagenomic sequences from complex sequence populations. BMC Bioinformatics. 2016 Jul 28;17:292. doi: 10.1186/s12859-016-1159-6. PubMed PMID: 27465705; PubMed Central PMCID: PMC4963998. Read more about this paper here...

• Lee AY, Day AC, Egan C, Bailey C, Johnston RL, Tsaloumas MD, Denniston AK, Tufail A. Previous Intravitreal Therapy Is Associated with Increased Risk of Posterior Capsule Rupture during Cataract Surgery. Ophthalmology. 2016 Jun;123(6):1252-6. doi: 10.1016/j.ophtha.2016.02.014. Epub 2016 Mar 18. PubMed PMID: 26996340. Read more about this paper here...

• Lee AY, Lee CS, Keane PA, Tufail A. Use of Mechanical Turk as a MapReduce Framework for Macular OCT Segmentation. J Ophthalmol. 2016;2016:6571547. doi: 10.1155/2016/6571547. Epub 2016 May 11. PubMed PMID: 27293877; PubMed Central PMCID: PMC4879255. Read more about this paper here...

• Zhang Q, Lee CS, Chao J, Chen CL, Zhang T, Sharma U, Zhang A, Liu J, Rezaei K, Pepple KL, Munsen R, Kinyoun J, Johnstone M, Van Gelder RN, Wang RK. Wide-field optical coherence tomography based microangiography for retinal imaging. Sci Rep. 2016 Feb 25;6:22017. doi: 10.1038/srep22017. PubMed PMID: 26912261; PubMed Central PMCID: PMC4766473.

• Lee CS, Agrawal R, Pavesio C. Ocular Tuberculosis--A Clinical Conundrum. Ocul Immunol Inflamm. 2016;24(2):237-42. doi: 10.3109/09273948.2014.985387. Epub 2015 Jun 25. PubMed PMID: 26110355; PubMed Central PMCID: PMC4760910.

• Agrawal R, Lee CS, Gonzalez-Lopez JJ, Khan S, Rodrigues V, Pavesio C. Flurbiprofen: A Nonselective Cyclooxygenase (COX) Inhibitor for Treatment of Noninfectious, Non-necrotizing Anterior Scleritis. Ocul Immunol Inflamm. 2016;24(1):35-42. doi: 10.3109/09273948.2015.1032308. Epub 2015 Aug 26. PubMed PMID: 26308394; PubMed Central PMCID: PMC4813454.

2015

• Kapetanakis VV, Rudnicka AR, Liew G, Owen CG, Lee AY, Louw V, Bolter L, Anderson J, Egan C, Salas-Vega S, Rudisill C, Taylor P, Tufail A. A study of whether automated Diabetic Retinopathy Image Assessment could replace manual grading steps in the English National Screening Programme. J Med Screen. 2015 Sep;22(3):112-8. doi: 10.1177/0969141315571953. Epub 2015 Mar 5. PubMed PMID: 25742804.

• Lee AY, Lee CS, Butt T, Xing W, Johnston RL, Chakravarthy U, Egan C, Akerele T, McKibbin M, Downey L, Natha S, Bailey C, Khan R, Antcliff R, Varma A, Kumar V, Tsaloumas M, Mandal K, Liew G, Keane PA, Sim D, Bunce C, Tufail A. UK AMD EMR USERS GROUP REPORT V: benefits of initiating ranibizumab therapy for neovascular AMD in eyes with vision better than 6/12. Br J Ophthalmol. 2015 Aug;99(8):1045-50. doi: 10.1136/bjophthalmol-2014-306229. Epub 2015 Feb 13. PubMed PMID: 25680619; PubMed Central PMCID: PMC4560462. Read more about this paper here...

• Sheybani A, Saboori M, Kim JM, Gammon H, Lee AY, Bhorade AM. Effect of endoscopic cyclophotocoagulation on refractive outcomes when combined with cataract surgery. Can J Ophthalmol. 2015 Jun;50(3):197-201. doi: 10.1016/j.jcjo.2015.03.006. PubMed PMID: 26040219.

• Lee CS, Harocopos GJ, Kraus CL, Lee AY, Van Stavern GP, Couch SM, Rao PK. IgG4-associated orbital and ocular inflammation. J Ophthalmic Inflamm Infect. 2015;5:15. doi: 10.1186/s12348-015-0047-y. eCollection 2015. PubMed PMID: 26034515; PubMed Central PMCID: PMC4446498. Read more about this paper here...

• Butt T, Lee AY, Lee CS, Tufail A. The cost-effectiveness of initiating ranibizumab therapy in eyes with neovascular AMD with good vision: an economic model using real-world outcomes. BMJ Open. 2015 May 5;5(5):e006535. doi: 10.1136/bmjopen-2014-006535. PubMed PMID: 25943370; PubMed Central PMCID: PMC4431059.

• Hong BK, Lee CS, Van Gelder RN, Garg SJ. Emerging techniques for pathogen discovery in endophthalmitis. Curr Opin Ophthalmol. 2015 May;26(3):221-5. doi: 10.1097/ICU.0000000000000145. Review. PubMed PMID: 25759963; PubMed Central PMCID: PMC4425405.

• Buckle M, Lee AY, Mohamed Q, Fletcher E, Sallam A, Healy R, Stratton I, Tufail A, Johnston RL. Prevalence and incidence of blindness and other degrees of sight impairment in patients treated for neovascular age-related macular degeneration in a well-defined region of the United Kingdom. Eye (Lond). 2015 Mar;29(3):403-8. doi: 10.1038/eye.2014.296. Epub 2015 Jan 16. PubMed PMID: 25592123; PubMed Central PMCID: PMC4366463.

• Lee AY, Akileswaran L, Tibbetts MD, Garg SJ, Van Gelder RN. Identification of torque teno virus in culture-negative endophthalmitis by representational deep DNA sequencing. Ophthalmology. 2015 Mar;122(3):524-30. doi: 10.1016/j.ophtha.2014.09.001. Epub 2014 Nov 24. PubMed PMID: 25439613; PubMed Central PMCID: PMC4339625. Read more about this paper here...

• Lee CS, Lee AY, Sim DA, Keane PA, Mehta H, Zarranz-Ventura J, Fruttiger M, Egan CA, Tufail A. Reevaluating the definition of intraretinal microvascular abnormalities and neovascularization elsewhere in diabetic retinopathy using optical coherence tomography and fluorescein angiography. Am J Ophthalmol. 2015 Jan;159(1):101-10.e1. doi: 10.1016/j.ajo.2014.09.041. Epub 2014 Oct 25. PubMed PMID: 25284762; PubMed Central PMCID: PMC5006953.

2014

• Earl JB, Lee CS, Yom V, Van Stavern GP, Abuattieh M, Chin-Yee D, Rao PK, Apte RS. Visual cycle suppression via patching in central serous chorioretinopathy. Ophthalmology. 2014 Dec;121(12):2502-4.e1. doi: 10.1016/j.ophtha.2014.06.038. Epub 2014 Aug 8. PubMed PMID: 25109933.

• Lee CS, Lee AY, Forooghian F, Bergstrom CS, Yan J, Yeh S. Fundus autofluorescence features in the inflammatory maculopathies. Clin Ophthalmol. 2014;8:2001-12. doi: 10.2147/OPTH.S68446. eCollection 2014. PubMed PMID: 25302012; PubMed Central PMCID: PMC4189704. Read more about this paper here...

• Lin P, Bach M, Asquith M, Lee AY, Akileswaran L, Stauffer P, Davin S, Pan Y, Cambronne ED, Dorris M, Debelius JW, Lauber CL, Ackermann G, Baeza YV, Gill T, Knight R, Colbert RA, Taurog JD, Van Gelder RN, Rosenbaum JT. HLA-B27 and human β2-microglobulin affect the gut microbiota of transgenic rats. PLoS One. 2014;9(8):e105684. doi: 10.1371/journal.pone.0105684. eCollection 2014. PubMed PMID: 25140823; PubMed Central PMCID: PMC4139385.

2012

• Sobrin L, Ripke S, Yu Y, Fagerness J, Bhangale TR, Tan PL, Souied EH, Buitendijk GH, Merriam JE, Richardson AJ, Raychaudhuri S, Reynolds R, Chin KA, Lee AY, Leveziel N, Zack DJ, Campochiaro P, Smith RT, Barile GR, Hogg RE, Chakravarthy U, Behrens TW, Uitterlinden AG, van Duijn CM, Vingerling JR, Brantley MA Jr, Baird PN, Klaver CC, Allikmets R, Katsanis N, Graham RR, Ioannidis JP, Daly MJ, Seddon JM. Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. Ophthalmology. 2012 Sep;119(9):1874-85. doi: 10.1016/j.ophtha.2012.03.014. Epub 2012 Jun 15. PubMed PMID: 22705344; PubMed Central PMCID: PMC3899891.

• Jung CS, Payne JF, Bergstrom CS, Cribbs BE, Yan J, Hubbard GB 3rd, Olsen TW, Yeh S. Multimodality diagnostic imaging in unilateral acute idiopathic maculopathy. Arch Ophthalmol. 2012 Jan;130(1):50-6. doi: 10.1001/archophthalmol.2011.359. PubMed PMID: 22232475; PubMed Central PMCID: PMC4116109.

2011

• Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, Souied EH, Richardson AJ, Merriam JE, Buitendijk GH, Reynolds R, Raychaudhuri S, Chin KA, Sobrin L, Evangelou E, Lee PH, Lee AY, Leveziel N, Zack DJ, Campochiaro B, Campochiaro P, Smith RT, Barile GR, Guymer RH, Hogg R, Chakravarthy U, Robman LD, Gustafsson O, Sigurdsson H, Ortmann W, Behrens TW, Stefansson K, Uitterlinden AG, van Duijn CM, Vingerling JR, Klaver CC, Allikmets R, Brantley MA Jr, Baird PN, Katsanis N, Thorsteinsdottir U, Ioannidis JP, Daly MJ, Graham RR, Seddon JM. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet. 2011 Sep 15;20(18):3699-709. doi: 10.1093/hmg/ddr270. Epub 2011 Jun 10. PubMed PMID: 21665990; PubMed Central PMCID: PMC3159552.

• Muthappan V, Lee AY, Lamprecht TL, Akileswaran L, Dintzis SM, Lee CS, Magrini V, Mardis ER, Shendure J, Van Gelder RN. Biome representational in silico karyotyping. Genome Res. 2011 Apr;21(4):626-33. doi: 10.1101/gr.115758.110. Epub 2011 Feb 10. PubMed PMID: 21324882; PubMed Central PMCID: PMC3065710.

2010

• Lee AY, Kulkarni M, Fang AM, Edelstein S, Osborn MP, Brantley MA. The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration. Br J Ophthalmol. 2010 Jul;94(7):915-7. doi: 10.1136/bjo.2009.172007. PubMed PMID: 20606025; PubMed Central PMCID: PMC3655725.

• Neale BM, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, Tan PL, Oh EC, Merriam JE, Souied E, Bernstein PS, Li B, Frederick JM, Zhang K, Brantley MA Jr, Lee AY, Zack DJ, Campochiaro B, Campochiaro P, Ripke S, Smith RT, Barile GR, Katsanis N, Allikmets R, Daly MJ, Seddon JM. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7395-400. doi: 10.1073/pnas.0912019107. Epub 2010 Apr 12. PubMed PMID: 20385826; PubMed Central PMCID: PMC2867697. 

2009

• Fang AM, Lee AY, Kulkarni M, Osborn MP, Brantley MA Jr. Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration. Mol Vis. 2009 Dec 10;15:2710-9. PubMed PMID: 20019880; PubMed Central PMCID: PMC2793900.

• Jung CS, Hubbard GB 3rd, Grossniklaus HE. Giant Cell Astrocytoma of the Retina in a 1-Month-Old Infant. J Pediatr Ophthalmol Strabismus. 2009 Nov 2;. doi: 10.3928/01913913-20091019-05. Epub 2009 Nov 2. PubMed PMID: 19873950; PubMed Central PMCID: PMC3040785.

2008

• Jung CS, Bruce B, Newman NJ, Biousse V. Visual function in anterior ischemic optic neuropathy: effect of Vision Restoration Therapy--a pilot study. J Neurol Sci. 2008 May 15;268(1-2):145-9. doi: 10.1016/j.jns.2007.12.001. Epub 2008 Jan 22. PubMed PMID: 18207164.

• Lee AY, Raya AK, Kymes SM, Shiels A, Brantley MA Jr. Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab. Br J Ophthalmol. 2009 May;93(5):610-3. doi: 10.1136/bjo.2008.150995. Epub 2008 Dec 17. PubMed PMID: 19091853; PubMed Central PMCID: PMC3490485.

• Lee AY, Brantley MA Jr. CFH and LOC387715/ARMS2 genotypes and antioxidants and zinc therapy for age-related macular degeneration. Pharmacogenomics. 2008 Oct;9(10):1547-50. doi: 10.2217/14622416.9.10.1547. PubMed PMID: 18855541.

2007

• Jung CS, Zhou Z, Khuri FR, Sun SY. Assessment of apoptosis-inducing effects of docetaxel combined with the proteasome inhibitor PS-341 in human lung cancer cells. Cancer Biol Ther. 2007 May;6(5):749-54. doi: 10.4161/cbt.6.5.3977. Epub 2007 Feb 7. PubMed PMID: 17387269.