big data – Page 3 – Computational Ophthalmology

July 28, 2016September 27, 2020

Scalable metagenomics alignment research tool (SMART): a scalable, rapid, and complete search heuristic for the classification of metagenomic sequences from complex sequence populations

In this study, the authors address a relatively new computational challenge: how to to rapidly and accurately identify species-level DNA sequences from next generation metagenomic shotgun sequencing data. NCBI Genbank (v209), the ever-growing library of sequenced DNA fragments mapped to an identified taxonomy species, has an enormous catalog (1.99 x 10¹¹ basepairs of cDNA and genomic DNA from 1.87 x 10⁸ records at the time of this study). Sequence alignment software is used to match unknown DNA sequences to the catalog of identified genetic data, but new approaches are needed to manage the increasing data. In this study, the authors aimed to validate a Scalable Metagenomics Alignment Research Tool (SMART), a novel searching heuristic for shotgun metagenomics sequencing results.

June 15, 2016September 27, 2020

Previous Intravitreal Therapy Is Associated with Increased Risk of Posterior Capsule Rupture during Cataract Surgery

Pubmed

Journal

Citation

In this multicenter, national electronic medical record database study, Dr. Lee and his coauthors investigated whether previous intravitreal therapy is a predictor of posterior capsule rupture during cataract surgery. Posterior capsule rupture occurs in approximately 1.9% to 2.1% of cataract surgeries and is the only potentially modifiable risk indicator for visual loss after cataract surgery. There are many known risk factors for posterior capsule rupture, but the significance of previous intravitreal therapy, an increasingly common treatment for several ophthalmic conditions, as a risk factor for this complication of cataract surgery is unknown.